In this paper, we present a framework for cell manipulation tasks with visual servoing micromanipulation strategies. A vision based micropositioner is designed in order to address the requirement of high precision needed to perform manipulation of objects under 100 microns in size. The system calibration (microscope-camera-micropositioner) and the model of the observed scene are not known. Experimental results for micropositoning tasks with respect to protein cells are presented and demonstrate the validity of the proposed approach.